Development of ionic liquid microemulsion for transdermal delivery of a chemotherapeutic agent

Abstract Nowadays skin cancers have become a major area of concern because the continuous exposure to sun rays (UV rays). Hence, present work focused on synthesis an innovative 5-Fluorouracil (5-FU) microemulsion as topical delivery system mainly used treat various forms cancer. The administration most active compounds is impaired by limited permeability due presence barriers. In this sequence, represents cost-effective and convenient drug carrier that successfully delivers across skin. Unfortunately, 5-FU reveals high toxicity low tumor affinity became inefficient for patients with risk serious side effects. For decreasing eluding some its disadvantages we made it more effective preparing tween 80 (surfactant), isopropyl alcohol (co-surfactant), oleic acid (oil) in four-component system. This study emphasized increasing release multiple times gel has been formulated designs elongate release. All preparation was characterized physicochemical studies. size 550–600 nm confirmed transmission electron microscopy (TEM) Zetasizer. clear prepared at pH 5–6. It shows viscosity limit 13.52–18.23 Pa s. outcome satisfactory cancer treatment.